A nitro radical anion formation from nifedipine: an electrochemical approach

Abstract

The cyclic voltammetric behaviour of nifedipine was studied. The addition of three aprotic solvents to nifedipine in an aqueous citrate buffer system was examined. Qualitatively they result in separation of the initial irreversible 4 electron reduction into two stages, the NO2/RNO. 2 - and RNO. 2 -, 4H+/RNHOH, H2O couples, respectively. Particular attention was directed to the 1-electron RNO2/RNO. 2 - couple as measured by the cyclic voltammetric mode in mixed media. Analysis of the cyclic voltammetric response as a function of scan rate and non-aqueous solvent content yields information on the stability of the radical anion. The chemical forward reaction of the radical anion follows a second order kinetics with a stability constant of 1.1 × 10-3 l mol-1 s-1 and a half-life time of 0.09 s for 1 mM of nifedipine in aqueous citrate buffer, pH 7.4/DMF; 50:50. © 1993.