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Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorDíaz Araya, Guillermo 
Authordc.contributor.authorOlea Azar, Claudio 
Authordc.contributor.authorAtria Salas, Ana María 
Authordc.contributor.authorBollo Dragnic, Soledad 
Authordc.contributor.authorSquella Serrano, Juan
Admission datedc.date.accessioned2018-12-20T15:09:20Z
Available datedc.date.available2018-12-20T15:09:20Z
Publication datedc.date.issued1998
Cita de ítemdc.identifier.citationPharmaceutical Research, Volumen 15, Issue 11, 2018, Pages 1690-1695
Identifierdc.identifier.issn07248741
Identifierdc.identifier.other10.1023/A:1011948410183
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158025
Abstractdc.description.abstractPurpose. To determine the formation of the one-electron reduction product from nisoldipine and its reactivity with relevant thiols in mixed medium. Methods. Cyclic voltammetry (CV) and electron paramagnetic resonance (EPR) techniques were used to determine the one-electron reduction product corresponding to the nitro radical anion. CV was employed to assess both the rate constants corresponding to the decay of the radicals and its interaction with relevant thiols. Results. The nisoldipine radical anion follows second order kinetics, with an association rate constant of 283 ± 16 lmol-1 sec- 1. Nitro radical artion from nisoldipine significantly reacted with thiol compounds. This reactivity was significantly higher than the natural decay of the radical in mixed medium. EPR spectra recorded in situ using DMF/ 0.1 N NaOH (pH 13) confirmed the formation of the nitro radical anion, giving a well-resolved spectra in 35 lines using 0.1 G modulation. Conclusions. Electrochemical and EPR data in
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePharmaceutical Research
Keywordsdc.subjectCyclic voltammetry
Keywordsdc.subjectEPR spectroscopy
Keywordsdc.subjectFiitro radical anion
Keywordsdc.subjectNisoldipine
Keywordsdc.subjectScavenging
Keywordsdc.subjectThiol
Títulodc.titleScavenging of the one-electron reduction product from nisoldipine with relevant thiols: Electrochemical and EPR spectroscopic evidences
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile