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Authordc.contributor.authorDíaz Araya, Guillermo 
Authordc.contributor.authorGodoy, L. 
Authordc.contributor.authorNaranjo, L. 
Authordc.contributor.authorSquella, A. 
Authordc.contributor.authorLetelier, M. E. 
Authordc.contributor.authorNúñez Vergara, Luis
Admission datedc.date.accessioned2018-12-20T15:09:20Z
Available datedc.date.available2018-12-20T15:09:20Z
Publication datedc.date.issued1998
Cita de ítemdc.identifier.citationGeneral Pharmacology, Volumen 31, Issue 3, 2018, Pages 385-391
Identifierdc.identifier.issn03063623
Identifierdc.identifier.other10.1016/S0306-3623(98)00034-2
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/158027
Abstractdc.description.abstractLipid peroxidation in rat brain slices was induced by Fe+3/ascorbate.Brain lipid peroxidation, as measured by malondialdehyde formation, was inhibited by all the tested nitro aryl 1,4-dihydropyridine derivatives over a wide range of concentrations. The time-course antioxidant effects of the most representative agents were assessed. On the basis of both time-course and IC50 experiments the tentative order of antioxidant activity on rat brain slices could be: nicardipine>nisoldipine>(R,S/S,R)-furnidipine>(R,R/S,S)-furnidipine>nitrendipine>nimodipine>nifedipine.1,4-Dihydropyridine derivatives that lack of a nitro group in the molecule (isradipine, amlodipine) also inhibited lipid peroxidation in rat brain slices but at higher concentrations than that of nitro-substituted derivatives.All the tested nitroso aryl derivatives [2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (NTP), nitrosotoluene, nitrosobenzene] were more potent inhibitors of lipid peroxidation t
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceGeneral Pharmacology
Keywordsdc.subjectAntioxidant
Keywordsdc.subjectLipoperoxidation
Keywordsdc.subjectNitroaryl 1,4-dihydropyridines
Keywordsdc.subjectNitroso derivatives
Títulodc.titleAntioxidant effects of 1,4-dihydropyridine and niitroso aryl derivatives on the Fe+3/ascorbate-stimulated lipid peroxidation in rat brain slices
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile