Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy
Author
dc.contributor.author
Ebensperger González, Roberto
Author
dc.contributor.author
Acevedo, Erika
Author
dc.contributor.author
Meléndez, Jaime
Author
dc.contributor.author
Corbalán, Ramón
Author
dc.contributor.author
Acevedo, Mónica
Author
dc.contributor.author
Sapag Hagar, Mario
Author
dc.contributor.author
Jalil Milad, Jorge
Author
dc.contributor.author
Lavandero González, Sergio
Admission date
dc.date.accessioned
2018-12-20T15:09:20Z
Available date
dc.date.available
2018-12-20T15:09:20Z
Publication date
dc.date.issued
1998
Cita de ítem
dc.identifier.citation
Biochemical and Biophysical Research Communications, Volumen 243, Issue 1, 2018, Pages 20-24
Identifier
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0006291X
Identifier
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10.1006/bbrc.1997.8031
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/158030
Abstract
dc.description.abstract
There is evidence that insulin-like growth factor-1 (IGF-1) plays a role in the development of left ventricular hypertrophy, but it is uncertain whether cardiac IGP-1 changes before or after hypertension is established, and whether circulating IGF-1 are involved in cardiac hypertrophy. We have investigated changes in circulating and left ventricular IGF-1 and in the expression of the IGF-1 gene in the left ventricles of rats during the development of hypertensive left ventricular hypertrophy (Goldblatt model; 2 kidney-1 clamped). Our results show that the left ventricular contents of IGF-1 and its mRNA were increased at one and four weeks of hypertension and hypertrophy, and that both returned to control values after nine weeks. These changes were unrelated to the seric concentration of IGF-1 in the blood. These results show that local rather than circulating IGF-1 levels contributed to the development of renovascular hypertensive left ventricular hypertrophy.