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Authordc.contributor.authorMarchant, 
Authordc.contributor.authorLinker, 
Authordc.contributor.authorRuiz, 
Authordc.contributor.authorGuerrero, 
Authordc.contributor.authorMayor, 
Admission datedc.date.accessioned2018-12-20T15:09:20Z
Available datedc.date.available2018-12-20T15:09:20Z
Publication datedc.date.issued1998
Cita de ítemdc.identifier.citationDevelopmental Biology, Volumen 198, Issue 2, 2018, Pages 319-329
Identifierdc.identifier.issn00121606
Identifierdc.identifier.other10.1006/dbio.1998.8902
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/158031
Abstractdc.description.abstractWe have analyzed the role of mesoderm in the induction of the neural crest in Xenopus using expression of neural plate (Xsox-2) and neural crest (Xslug and ADAM). Conjugation experiments using different kinds of mesoderm together with embryonic dissection experiments suggest that the dorsolateral mesoderm is capable of specifically inducing neural crest cells. Neural crest markers can be induced in competent ectoderm at varying distances from the inducing mesoderm, with dorsal tissue inducing neural crest at a distance while dorsolateral tissue only induces neural crest directly in adjacent ectoderm. The results suggest that dorsal mesoderm has a high level of inducer and dorsolateral mesoderm has a lower level, consistent with a inductive gradient. We explored the possible role of BMP and noggin in the generation of such a hypothetical gradient and found that: (1) progressively higher levels of BMP activity are sufficient for the specification of neural plate, neural crest, and nonneu
Lenguagedc.language.isoen
Publisherdc.publisherAcademic Press Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceDevelopmental Biology
Keywordsdc.subjectBMP
Keywordsdc.subjectGradient
Keywordsdc.subjectMesoderm
Keywordsdc.subjectMyoD
Keywordsdc.subjectNeural crest
Keywordsdc.subjectNeural induction
Keywordsdc.subjectNeural plate
Keywordsdc.subjectNoggin
Keywordsdc.subjectXenopus laevis
Keywordsdc.subjectXslug
Keywordsdc.subjectXsox- 2
Títulodc.titleThe inductive properties of mesoderm suggest that the neural crest cells are specified by a BMP gradient
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile