The effect of fenoldopam on the blood pressure of the rat
Author
dc.contributor.author
Quevedo,
Author
dc.contributor.author
Prieto,
Author
dc.contributor.author
Perez-Olea,
Admission date
dc.date.accessioned
2018-12-20T15:09:21Z
Available date
dc.date.available
2018-12-20T15:09:21Z
Publication date
dc.date.issued
1999
Cita de ítem
dc.identifier.citation
General Pharmacology, Volumen 32, Issue 1, 2018, Pages 123-125
Identifier
dc.identifier.issn
03063623
Identifier
dc.identifier.other
10.1016/S0306-3623(98)00065-2
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/158036
Abstract
dc.description.abstract
1. Fenoldopam mesylate, a benzazepine derivative, is a D1 receptor agonist that lowers blood pressure through vasodilation of renal, mesenteric, coronary and cerebral vascular beds. 2. Experiments were performed in rats, and mean carotid blood pressure and heart rate were registered. Two series of experiments were performed: (1) fenoldopam as control group and (2) fenoldopam after pretreatment with one of the following drugs: the D1 antagonist SCH 23390, the D2 antagonist sulpiride, the selective β1-adrenergic antagonist atenolol, the selective β2-adrenergic antagonist ICI 118.551, the nonselective β-adrenergic antagonist propranolol and the neurotoxin that destroys catecholaminergic nerve terminals 6-hydroxydopamine (6-OH-DA). 3. Fenoldopam produced a dose-dependent hypotensive effect that was not modified by pretreatment of the rat with atenolol or propranolol; however, ICI 118.551 produced a significant reduction of the hypotensive response induced by fenoldopam. 4. Pretreatment of