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Authordc.contributor.authorSpeisky Cosoy, Hernán 
Authordc.contributor.authorGómez, Maritza 
Authordc.contributor.authorCarrasco Pozo, Catalina 
Authordc.contributor.authorPastene, Edgar 
Authordc.contributor.authorLópez Alarcón, Camilo 
Authordc.contributor.authorOlea Azar, Claudio 
Cita de ítemdc.identifier.citationBioorganic and Medicinal Chemistry, Volumen 16, Issue 13, 2008, Pages 6568-6574
Abstractdc.description.abstractCu(2+) ions and and GSH molecules interact swiftly to form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing Cu(I)–glutathione led to a sustained decline of the basal oxygen level. Such effect was partially reverted by the addition of catalase. The complex was able to induce the reduction of cytochrome c and the oxidation of dyhydroethidium into 2-hydroxyethidium. Both effects were totally blocked by SOD. The ability of the complex to generate superoxide radicals was confirmed by EPR spin-trapping. Cu(I)–glutathione induces no oxidation of fluorescein, a hydroxyl radical-sensitive probe. We conclude that in solutions containing the complex, oxygen is continually reduced into superoxide, and that—in absence of interceptors—the latter radicals are quantitatively re-oxidized into molecular oxygen. We suggest that, by functioning as a continuous source of superoxide, the complex could potentially affect a broad range of susceptible biological targets.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBioorganic and Medicinal Chemistry
Keywordsdc.subjectCopper-glutathione complex
Keywordsdc.subjectSuperoxide radicals
Títulodc.titleCu(I)-Glutathione complex: A potential source of superoxide radicals generation
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile