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Authordc.contributor.authorAndrés, Sergio 
Authordc.contributor.authorCárdenas, Sergio 
Authordc.contributor.authorLecocq Parra, Claudio 
Authordc.contributor.authorBravo, Javier 
Authordc.contributor.authorGreiner, Monika 
Authordc.contributor.authorRojas, Paulina 
Authordc.contributor.authorMorales, Paola 
Authordc.contributor.authorLara Peñaloza, Hernán 
Authordc.contributor.authorFiedler Temer, Jenny 
Admission datedc.date.accessioned2018-12-20T15:10:07Z
Available datedc.date.available2018-12-20T15:10:07Z
Publication datedc.date.issued2006
Cita de ítemdc.identifier.citationEndocrine, Volumen 29, Issue 2, 2018, Pages 299-307
Identifierdc.identifier.issn1355008X
Identifierdc.identifier.other10.1385/ENDO:29:2:299
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/158149
Abstractdc.description.abstractReduction in corticosterone by acute adrenalectomy (5 d) promotes apoptosis in dentate gyrus (DG) granular neurons, an effect concomitant with variations in the expression of the Bcl-2 gene family implicated in apoptotic regulation. However, no studies exist correlating the effect of long-term adrenalectomy (30 d) on the hippocampus in terms of extent of apoptosis and the levels of proteins related to an apoptotic cascade. After 5 d of adrenalectomy, we found an increase in apoptosis of the DG granular region, correlated with an increase in the processing of caspase-9. The magnitude of apoptosis 30 d after adrenalectomy was reduced in the DG granular layer compared with 5 d after adrenalectomy, in close relation to a reduction in the level of processed caspase-9. To understand how the increase in cell survival long after adrenalectomy occurs, we analyzed changes in the expression of genes and proteins related to apoptosis. Long-term adrenalectomy did not change hippocampal pro-apoptoti
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceEndocrine
Keywordsdc.subjectAdrenalectomy
Keywordsdc.subjectApoptosis
Keywordsdc.subjectBAD
Keywordsdc.subjectBAX
Keywordsdc.subjectBCL-2
Keywordsdc.subjectBCL-XL
Keywordsdc.subjectCorticosterone
Títulodc.titleEffects of long-term adrenalectomy on apoptosis and neuroprotection in the rat hippocampus
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile