Mostrar el registro sencillo del ítem

Autordc.contributor.authorKlein, Andres 
Autordc.contributor.authorMaldonado, Carola 
Autordc.contributor.authorVargas, Lina M. 
Autordc.contributor.authorGonzalez, Marcela 
Autordc.contributor.authorRobledo, Fermín 
Autordc.contributor.authorPerez de Arce, Karen 
Autordc.contributor.authorMuñoz, Francisco J. 
Autordc.contributor.authorHetz Flores, Claudio 
Autordc.contributor.authorAlvarez, Alejandra R. 
Autordc.contributor.authorZanlungo, Silvana 
Fecha ingresodc.date.accessioned2018-12-20T15:10:28Z
Fecha disponibledc.date.available2018-12-20T15:10:28Z
Fecha de publicacióndc.date.issued2011
Cita de ítemdc.identifier.citationNeurobiology of Disease, Volumen 41, Issue 1, 2018, Pages 209-218
Identificadordc.identifier.issn09699961
Identificadordc.identifier.other10.1016/j.nbd.2010.09.008
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/158196
Resumendc.description.abstractNiemann-Pick type C (NPC) is a neurodegenerative disease characterized by the intralysosomal accumulation of cholesterol leading to neuronal apoptosis. We have previously reported the activation of the c-Abl/p73 proapoptotic pathway in the cerebellum of NPC mice; however, upstream signals underlying the engagement of this pathway remain unknown. Here, we investigate the possible role of oxidative stress in the activation of c-Abl/p73 using different in vitro and in vivo NPC models. Our results indicate a close temporal correlation between the appearance of nitrotyrosine (N-Tyr; a post-translational tyrosine modification caused by oxidative stress) and the activation of c-Abl/p73 in NPC models. To test the functional role of oxidative stress in NPC, we have treated NPC neurons with the antioxidant NAC and observed a dramatic decrease of c-Abl/p73 activation and a reduction in the levels of apoptosis in NPC models. In conclusion, our data suggest that oxidative stress is the main upstrea
Idiomadc.language.isoen
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceNeurobiology of Disease
Palabras clavesdc.subjectApoptosis
Palabras clavesdc.subjectC-Abl/p73
Palabras clavesdc.subjectNeurodegeneration
Palabras clavesdc.subjectNiemann-Pick type C
Palabras clavesdc.subjectOxidative stress
Títulodc.titleOxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons
Tipo de documentodc.typeArtículo de revista
Catalogadoruchile.catalogadorSCOPUS
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Descargar archivo

Icon

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile