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Authordc.contributor.authorIglewski, Myriam 
Authordc.contributor.authorHill, Joseph A. 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorRothermel, Beverly A. 
Admission datedc.date.accessioned2018-12-20T15:10:29Z
Available datedc.date.available2018-12-20T15:10:29Z
Publication datedc.date.issued2010
Cita de ítemdc.identifier.citationCurrent Hypertension Reports, Volumen 12, Issue 6, 2018, Pages 418-425
Identifierdc.identifier.issn15226417
Identifierdc.identifier.other10.1007/s11906-010-0147-x
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/158202
Abstractdc.description.abstractSustained hypertension promotes structural, functional and metabolic remodeling of cardiomyocyte mitochondria. As long-lived, postmitotic cells, cardiomyocytes turn over mitochondria continuously to compensate for changes in energy demands and to remove damaged organelles. This process involves fusion and fission of existing mitochondria to generate new organelles and separate old ones for degradation via autophagy. Autophagy is a lysosome-dependent proteolytic pathway capable of processing cellular components, including organelles and protein aggregates. Autophagy can be either nonselective or selective and contributes to remodeling of the myocardium under stress. Fission of mitochondria, loss of membrane potential, and ubiquitination are emerging as critical steps that direct selective autophagic degradation of mitochondria. This review discusses the molecular mechanisms controlling mitochondrial dynamics, including fission, fusion, transport, and degradation. Furthermore, it examine
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceCurrent Hypertension Reports
Keywordsdc.subjectAutophagy
Keywordsdc.subjectHeart failure
Keywordsdc.subjectHypertension
Keywordsdc.subjectMetabolism
Keywordsdc.subjectMitochondrial dynamics
Keywordsdc.subjectMitochondrial fission
Keywordsdc.subjectMitochondrial fusion
Keywordsdc.subjectMitophagy
Títulodc.titleMitochondrial fission and autophagy in the normal and diseased heart
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile