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Authordc.contributor.authorAravena, María C. 
Authordc.contributor.authorOlea Azar, Claudio 
Authordc.contributor.authorCerecetto, Hugo 
Authordc.contributor.authorGonzález, Mercedes 
Authordc.contributor.authorMaya Arango, Juan 
Authordc.contributor.authorRodríguez Becerra, Jorge 
Admission datedc.date.accessioned2018-12-20T15:10:30Z
Available datedc.date.available2018-12-20T15:10:30Z
Publication datedc.date.issued2011
Cita de ítemdc.identifier.citationSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Volumen 79, Issue 2, 2018, Pages 312-319
Identifierdc.identifier.issn13861425
Identifierdc.identifier.other10.1016/j.saa.2011.02.007
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158211
Abstractdc.description.abstractCyclic voltammetry and electron spin resonance techniques were used in the investigation of several potential antiprotozoal containing thiosemicarbazone and carbamate nitrofurans. In the electrochemical behaviour, a self-protonation process involving the nitro group was observed. The reactivity of the nitro anion radical for these derivatives with glutathione, a biological relevant thiol, was also studied in means of cyclic voltammetry. These studies demonstrated that glutathione could react with radical species from 5-nitrofuryl system. Furthermore, from the voltammetric results, some parameters of biological significance as E71 (indicative of the biological nitro anion radical formation), and KO2 (thermodynamic indicator the of oxygen redox cycling) have been calculated. We also evaluated the stability of the nitro anion radical in terms of the dimerization constant (kd). The nitrofuran-free radicals from cyclic voltammetry were characterized by electron spin resonance. A clear depen
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Keywordsdc.subjectCyclic voltammetry
Keywordsdc.subjectCytotoxicity
Keywordsdc.subjectESR
Keywordsdc.subjectNitrofuran
Keywordsdc.subjectT. cruzi
Títulodc.titlePotent 5-nitrofuran derivatives inhibitors of Trypanosoma cruzi growth: Electrochemical, spectroscopic and biological studies
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile