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Authordc.contributor.authorGuerrero, Simon 
Authordc.contributor.authorHerance, José 
Authordc.contributor.authorRojas, Santiago 
Authordc.contributor.authorMena, Juan 
Authordc.contributor.authorGispert, Juan 
Authordc.contributor.authorAcosta, Gerardo 
Authordc.contributor.authorAlbericio, Fernando 
Authordc.contributor.authorKogan Bocian, Marcelo 
Cita de ítemdc.identifier.citationBioconjugate Chemistry, Volumen 23, Issue 3, 2012, Pages 399-408
Abstractdc.description.abstractGold nanoparticles (AuNPs) have been extensively used in biological applications because of their biocompatibility, size, and ease of characterization, as well as an extensive knowledge of their surface chemistry. These features make AuNPs readily exploitable for biomedical applications, including drug delivery and novel diagnostic and therapeutic approaches. In a previous work, we studied ex vivo distribution of the conjugate C(AuNP)-LPFFD for its potential uses in the treatment of Alzheimer’s disease. In this study, we covalently labeled the conjugate with [18F]-fluorobenzoate to study the in vivo distribution of the AuNP by positron emission tomography (PET). After intravenous administration in rat, the highest concentration of the radiolabeled conjugate was found in the bladder and urine with a lower proportion in the intestine, demonstrating progressive accumulation compatible with biliary excretion of the conjugate. The conjugate also accumulated in the liver and spleen. PET imaging allowed us to study the in vivo biodistribution of the AuNPs in a noninvasive and sensitive way using a reduced number of animals. Our results show that AuNPs can be covalently and radioactively labeled for PET biodistribution studies.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBioconjugate Chemistry
Keywordsdc.subjectBiomedical engineering
Keywordsdc.subjectPharmaceutical science
Keywordsdc.subjectOrganic chemistry
Títulodc.titleSynthesis and in vivo evaluation of the biodistribution of a 18F-labeled conjugate gold-nanoparticle-peptide with potential biomedical application
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile