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Author | dc.contributor.author | Díaz Urrutia, Christian | |
Author | dc.contributor.author | Olea Azar, Claudio | |
Author | dc.contributor.author | Zapata, Gerald A. | |
Author | dc.contributor.author | Lapier, Michel | |
Author | dc.contributor.author | Mura Mardones, Francisco | |
Author | dc.contributor.author | Aguilera Venegas, Benjamín | |
Author | dc.contributor.author | Arán, Vicente J. | |
Author | dc.contributor.author | López Muñoz, Rodrigo | |
Author | dc.contributor.author | Maya Arango, Juan | |
Admission date | dc.date.accessioned | 2018-12-20T15:10:35Z | |
Available date | dc.date.available | 2018-12-20T15:10:35Z | |
Publication date | dc.date.issued | 2012 | |
Cita de ítem | dc.identifier.citation | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Volumen 95, | |
Identifier | dc.identifier.issn | 13861425 | |
Identifier | dc.identifier.other | 10.1016/j.saa.2012.04.076 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/158255 | |
Abstract | dc.description.abstract | A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic voltammetry were characterized by electron spin resonance spectroscopy (ESR) and their spectral lines were explained and analyzed using simulated spectra. In addition, we examined the interaction between radical species generated from nitroindazole derivatives and glutathione (GSH). Biological assays such as activity against Trypanosoma cruzi and cytotoxicity against macrophages were carried out. Finally, spin trapping and molecular modeling studies were also done in order to elucidate the potentials action mechanisms involved in the trypanocidal activity. © 2012 Elsevier B.V. All rights reserved. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | |
Keywords | dc.subject | Cyclic voltammetry | |
Keywords | dc.subject | ESR | |
Keywords | dc.subject | Free radicals | |
Keywords | dc.subject | Tetracyclic indazoles | |
Keywords | dc.subject | Theoretical calculations | |
Keywords | dc.subject | Trypanocidal activity | |
Título | dc.title | Biological and chemical study of fused tri- and tetracyclic indazoles and analogues with important antiparasitic activity | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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