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Authordc.contributor.authorDíaz Urrutia, Christian 
Authordc.contributor.authorOlea Azar, Claudio 
Authordc.contributor.authorZapata, Gerald A. 
Authordc.contributor.authorLapier, Michel 
Authordc.contributor.authorMura Mardones, Francisco 
Authordc.contributor.authorAguilera Venegas, Benjamín 
Authordc.contributor.authorArán, Vicente J. 
Authordc.contributor.authorLópez Muñoz, Rodrigo 
Authordc.contributor.authorMaya Arango, Juan 
Cita de ítemdc.identifier.citationSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Volumen 95,
Abstractdc.description.abstractA series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic voltammetry were characterized by electron spin resonance spectroscopy (ESR) and their spectral lines were explained and analyzed using simulated spectra. In addition, we examined the interaction between radical species generated from nitroindazole derivatives and glutathione (GSH). Biological assays such as activity against Trypanosoma cruzi and cytotoxicity against macrophages were carried out. Finally, spin trapping and molecular modeling studies were also done in order to elucidate the potentials action mechanisms involved in the trypanocidal activity. © 2012 Elsevier B.V. All rights reserved.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Keywordsdc.subjectCyclic voltammetry
Keywordsdc.subjectFree radicals
Keywordsdc.subjectTetracyclic indazoles
Keywordsdc.subjectTheoretical calculations
Keywordsdc.subjectTrypanocidal activity
Títulodc.titleBiological and chemical study of fused tri- and tetracyclic indazoles and analogues with important antiparasitic activity
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile