Gold nanoparticle-membrane interactions: Implications in biomedicine
Author
dc.contributor.author
Riveros, Ana
Author
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Dadlani, Komal
Author
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Salas, Edison
Author
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Caballero, Leonardo
Author
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Melo, Francisco
Author
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Kogan Bocian, Marcelo
Admission date
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2018-12-20T15:10:55Z
Available date
dc.date.available
2018-12-20T15:10:55Z
Publication date
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2013
Cita de ítem
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Journal of Biomaterials and Tissue Engineering, Volumen 3, Issue 1, 2018, Pages 4-21
Identifier
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21579091
Identifier
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21579083
Identifier
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10.1166/jbt.2013.1067
Identifier
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https://repositorio.uchile.cl/handle/2250/158306
Abstract
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There has been an increase in the research towards the use of nanoparticles as a promising tool for nanomedicine, from imagenology, drug and gene delivery, to phototherapy. Little is known regarding the interaction between nanoparticles and cell membranes despite its importance to achieve an efficient therapy avoiding adverse effects, such as cytotoxicity and accumulation in undesired targets. Gold nanoparticles have demonstrated to be a perfect candidate to use in biological systems because of their dimension, ease of characterization, biocompatibility, and ability to conjugate to different compounds, such as active peptides. There are different biophysical properties such as: shape, size, conjugation, surface charge and ligand arrangement that affect gold nanoparticlemembrane interactions. In this review we will analyze how these properties are involved in the mechanisms of interaction with membranes and the internalization pathways of gold nanoparticle systems into cells. A new appr