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Authordc.contributor.authorMorales, Pablo E. 
Authordc.contributor.authorTorres, Gloria 
Authordc.contributor.authorSotomayor Flores, Cristian Alejandro 
Authordc.contributor.authorPeña Oyarzún, Daniel 
Authordc.contributor.authorRivera Mejías, Pablo 
Authordc.contributor.authorParedes, Felipe 
Authordc.contributor.authorChiong Lay, Mario 
Admission datedc.date.accessioned2018-12-20T15:10:56Z
Available datedc.date.available2018-12-20T15:10:56Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationBiochemical and Biophysical Research Communications, Volumen 446, Issue 1, 2018, Pages 410-416
Identifierdc.identifier.issn10902104
Identifierdc.identifier.issn0006291X
Identifierdc.identifier.other10.1016/j.bbrc.2014.03.004
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158314
Abstractdc.description.abstractIncretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)-mitochondria communication, as it allows for a more efficient transfer of Ca2+ into the mitochondria, thereby increasing activity. Control of glucose metabolism is essential for proper vascular smooth muscle cell (VSMC) function. GLP-1 has been shown to produce varied metabolic actions, but whether it regulates glucose metabolism in VSMC remains unknown. In this report, we show that GLP-1 increases mitochondrial activity in the aortic cell line A7r5 by increasing ER-mitochondria coupling. GLP-1 increases intracellular glucose and diminishes glucose uptake without altering glycogen content. ATP, mitochondrial potential and oxygen consumption increase at 3 h of GLP-1 treatment, paralleled by increased Ca2+ transfer from the ER to the mitochondria. Furthermore, GLP-1 increases lev
Lenguagedc.language.isoen
Publisherdc.publisherAcademic Press Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiochemical and Biophysical Research Communications
Keywordsdc.subjectER-mitochondria coupling
Keywordsdc.subjectGLP-1
Keywordsdc.subjectMitochondrial metabolism
Keywordsdc.subjectMitofusin-2
Keywordsdc.subjectPKA
Keywordsdc.subjectVSMC
Títulodc.titleGLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile