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Authordc.contributor.authorLetelier, María E. 
Authordc.contributor.authorIturra Montecinos, Pablo 
Authordc.contributor.authorGallardo Garrido, Carlos 
Cita de ítemdc.identifier.citationBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, Volumen 16, Issue 2, 2017, Pages 88-98
Abstractdc.description.abstractInflammation is a cellular defensive mechanism associated to oxidative stress. The administration of nitrofurantoin, nifurtimox and acetaminophen generates oxidative stress by their biotransformation through CYP450 system. The main adverse effect described for the first two drugs is gastrointestinal inflammation and that of the last, hepatitis. Therefore, standardised dry extracts from Rosmarinus officinalis, Buddleja globosa Hope, Cynara scolymus L., Echinacea purpurea and Hedera helix were tested to evaluate their capacity to decrease drug-induced oxidative stress. For that, rat liver microsomes were incubated with drugs in the presence of NADPH (specific CYP450 system cofactor) to test oxidative damage on microsomal lipids, thiols, and GST activity. All drugs tested induced oxidation of micro somal lipids and thiols, and inhibition of GST activity. Herbal extracts prevented these phenomena in different extension. These results show that antioxidant phytodrugs previously evaluated could alleviate drugs adverse effects associated to oxidative stress.
Publisherdc.publisherUniversidad de Santiago de Chile
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Keywordsdc.subjectHerbal extracts
Keywordsdc.subjectHerbal thiols
Keywordsdc.subjectOxidation inhibition
Títulodc.titleHerbal extracts differentially inhibit oxidative effects caused by the biotransformation of nifurtimox, nitrofurantoin and acetaminophen on rat liver microsomes
Title in another languagedc.title.alternativeExtractos herbales inhiben diferencialmente los efectos oxidativos causados por la biotransformación nifurtimox, nitrofurantoína y acetaminofeno en microsomas hepáticos de rata
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile