Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents
| Author | dc.contributor.author | Tapia, Ricardo A. | |
| Author | dc.contributor.author | Carrasco, Claudia | |
| Author | dc.contributor.author | Ojeda, Scarlet | |
| Author | dc.contributor.author | Salas, Cristian | |
| Author | dc.contributor.author | Valderrama, Jaime A. | |
| Author | dc.contributor.author | Morello Casté, Antonio | |
| Author | dc.contributor.author | Repetto Scaramelli, Yolanda | |
| Admission date | dc.date.accessioned | 2018-12-20T15:20:33Z | |
| Available date | dc.date.available | 2018-12-20T15:20:33Z | |
| Publication date | dc.date.issued | 2002 | |
| Cita de ítem | dc.identifier.citation | Journal of Heterocyclic Chemistry, Volumen 39, Issue 5, 2018, Pages 1093-1096 | |
| Identifier | dc.identifier.issn | 0022152X | |
| Identifier | dc.identifier.other | 10.1002/jhet.5570390540 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/158819 | |
| Abstract | dc.description.abstract | The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described. A series of amides from esters (5) and (10) were also obtained. These compounds were tested in vitro as potential antitrypanosomal agents. Compounds (4) and (8) were found to have significant activity. | |
| Lenguage | dc.language.iso | en | |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| Source | dc.source | Journal of Heterocyclic Chemistry | |
| Keywords | dc.subject | Organic Chemistry | |
| Título | dc.title | Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents | |
| Document type | dc.type | Artículo de revista | |
| Cataloguer | uchile.catalogador | SCOPUS | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
| uchile.cosecha | uchile.cosecha | SI |
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