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Authordc.contributor.authorNúñez Vergara, Luis
Authordc.contributor.authorOrtiz, Luis J. 
Authordc.contributor.authorBollo Dragnic, Soledad 
Authordc.contributor.authorSquella Serrano, Juan 
Cita de ítemdc.identifier.citationChemico-Biological Interactions, Volumen 106, Issue 1, 2018, Pages 1-14
Abstractdc.description.abstractThis paper reports a comprehensive study by cyclic voltammetry on the electrochemical characteristics and the reactivity of the one-electron reduction product from a series of nitro aryl 1,4-dihydropyridines in mixed and aprotic media. In addition, the effects of 1,4-DHP on the oxygen consumption of T. cruzi epimastigotes are reported. One-electron reduction products from 1,4-DHP derivatives significantly reacted with both thiol compounds and the nuclei acid bases, adenine and uracil. This reactivity was significantly higher than the natural decay of the radicals in mixed media. Based on these results the following tentative order of reactivity towards the xeno/endobiotics is as follows: cysteamine > glutathione > adenineuracil. Both the stability and the reactivity of the nitro radical anions electrochemically generated from 1,4-DHP showed a linear dependence with pH. The sensitivity to pi-I of the radicals derived from o-nitro substituted derivatives was significantly higher than m-n
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceChemico-Biological Interactions
Keywordsdc.subjectCyclic voltammetry
Keywordsdc.subjectNitro radical anions
Keywordsdc.subjectT. cruzi
Títulodc.titleElectrochemical generation and reactivity of free radical redox intermediates from ortho-and meta-nitro substituted 1,4-dihydropyridines
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile