Author | dc.contributor.author | Núñez Vergara, Luis | |
Author | dc.contributor.author | Squella Serrano, Juan | |
Author | dc.contributor.author | Bollo Dragnic, Soledad | |
Author | dc.contributor.author | Morello Casté, Antonio | |
Author | dc.contributor.author | Repetto Scaramelli, Yolanda | |
Author | dc.contributor.author | Aldunate, Jorge | |
Author | dc.contributor.author | Letelier, María E. | |
Admission date | dc.date.accessioned | 2018-12-20T15:20:40Z | |
Available date | dc.date.available | 2018-12-20T15:20:40Z | |
Publication date | dc.date.issued | 1997 | |
Cita de ítem | dc.identifier.citation | Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, Volumen 118, Issue 1, 1997, Pages 105-111 | |
Identifier | dc.identifier.issn | 07428413 | |
Identifier | dc.identifier.other | 10.1016/S0742-8413(97)00078-9 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/158858 | |
Abstract | dc.description.abstract | A series of nitro aryl 1,4-dihydropyridine derivatives produced inhibition of both cell growth and oxygen consumption on Tulahuen and LQ strains, and clone Dm 28c of epimastigotes of Trypanosoma cruzi. Nicardipine was found to be the most potent derivative in both growth cell (I50 = 70 μM) and oxygen uptake (I50 = 26 μM in intact parasites, I50 = 325 μM in situ mitochondria). A correlation between the inhibitory effects on the growth cell and the apparent first order kinetic for the uptake of the 1,4-dihypyridine derivatives by T. cruzi epimastigotes was found. Thus, nicardipine, the most potent derivative, exhibited the highest apparent rate constant, k(u), (0.043 min-1). On the other hand, no susceptibility differences by strains and clone Dm 28c to the action of these drugs were found. | |
Lenguage | dc.language.iso | en | |
Source | dc.source | Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology | |
Keywords | dc.subject | Cathodic peak potential | |
Keywords | dc.subject | Cyclic voltammetry | |
Keywords | dc.subject | Diltiazem | |
Keywords | dc.subject | In situ mitochondria | |
Keywords | dc.subject | Nitro aryl 1,4-dihydropyridines | |
Keywords | dc.subject | Oxygen uptake | |
Keywords | dc.subject | Trypanosoma cruzi | |
Keywords | dc.subject | Uptake apparent rate constant | |
Keywords | dc.subject | Verapamil | |
Título | dc.title | Nitro aryl 1,4-dihydropyridine derivatives: Effects of Trypanosoma cruzi | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | |
Cataloguer | uchile.catalogador | rvh | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |