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Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorÁlvarez Lueje, Alejandro 
Authordc.contributor.authorSturm, 
Authordc.contributor.authorSunkel, 
Authordc.contributor.authorSquella Serrano, Juan 
Admission datedc.date.accessioned2018-12-20T15:20:40Z
Available datedc.date.available2018-12-20T15:20:40Z
Publication datedc.date.issued1998
Cita de ítemdc.identifier.citationAnalytical Letters, Volumen 31, Issue 12, 2018, Pages 2039-2051
Identifierdc.identifier.issn00032719
Identifierdc.identifier.other10.1080/00032719808005283
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158860
Abstractdc.description.abstractA systematic study of a new series of 4-methyl-1,4-dihydropyridine derivatives by HPLC by both photodiode array and electrochemical detectors is reported. The optimum mobile phase was acetonitrile/0.05 M phosphate buffer pH 3 (55/45, v/v) at a flow-rate of 1.5 mL/min. Compounds I-VIII were determined with UV detection at 250 nm and by electrochemical detection at + 1200 mV. Retention times varied between 3.0 and 14.0 minutes in the optimal experimental conditions. Good linear relationships between the peak areas and concentration were found, with limits of quantification ranging between 1 x 10-8 M and 1 x 10-6 M. Repeatability studies showed average variation coefficients lower than 1% for a photodiode array detector. No significant differences between the detectors in sensitivity and selectivity were found. Also, we used different degradation trials to test the selectivity of the methods. Results of these experiments revealed that the developed methods exhibited a good selectivity.
Lenguagedc.language.isoen
Publisherdc.publisherMarcel Dekker Inc.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAnalytical Letters
Keywordsdc.subject4-methyl-1,4-dihropyridines
Keywordsdc.subjectElectrochemical and photodiode array detection
Keywordsdc.subjectHPLC
Títulodc.titleSystematic HPLC study of a new series of 4-methyl-1,4-dihydropyridines with antitrombotic activity
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile