Quantum yields of singlet molecular oxygen, O2( 1Δg), produced by antimalaric drugs in organic solvents
Author
dc.contributor.author
Valencia U, Cristina
Author
dc.contributor.author
Lemp Miranda, Else
Author
dc.contributor.author
Zanocco Loyola, Antonio
Admission date
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2018-12-20T15:20:42Z
Available date
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2018-12-20T15:20:42Z
Publication date
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2003
Cita de ítem
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Journal of the Chilean Chemical Society, Volumen 48, Issue 4, 2018, Pages 17-21
Identifier
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07179324
Identifier
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https://repositorio.uchile.cl/handle/2250/158876
Abstract
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Detection of singlet molecular oxygen, O2(1Δ g), by phosphorescence emission, λ = 1270 nm, following laser excitation was employed to measure the quantum yield of O2( 1δg) generation by the antimalaric drugs quinine, quinacrine, chloroquine and primaquine in several organic solvents. The same method was employed to measure total rate constants, kT, for quenching (physical and chemical) of O2(1Δ g) by the antimalaric drugs. All drugs studied sensitize singlet oxygen formation in organic media. Quinine was the most efficient sensitizer in the four solvents employed. Three of the drugs under study, quinine, quinacrine and chloroquine, produced efficiently singlet molecular oxygen in ethanol. Also, the antimalaric drugs are relatively efficient quenchers of singlet oxygen. Values of kT range from (0.63 ± 0.02) × 107 M-1 s-1 for primaquine in hexane to (17.1 ± 0.30) × 107 M-1 s-1 for primaquine in acetonitrile. Data obtained show that undesirable adverse cutaneous and ocular side effects as