Psychotherapy and genetic neuroscience: an emerging dialog
Author
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Jiménez de la Jara, Juan Pablo
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Botto Valle, Alberto
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Herrera Cisterna, Luisa
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Leighton Geddes, Caroline
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Rossi Mery, José
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Quevedo Labbé, Iván
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Silva, Jaime R.
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Martínez, Felipe
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Assar, Rodrigo
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Salazar, Luis A.
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Ortiz, Manuel
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Ríos, Ulises
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Barros Vergara, Paulina
Author
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Jaramillo, Karina
Author
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Luyten, Patrick
Admission date
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2018-12-26T22:51:02Z
Available date
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2018-12-26T22:51:02Z
Publication date
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2018
Cita de ítem
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Frontiers in Genetics, vol 9, 2018 Article 257
es_ES
Identifier
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1664-8021
Identifier
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10.3389/fgene.2018.00257
Identifier
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https://repositorio.uchile.cl/handle/2250/159211
Abstract
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Recent research in psychiatric genetics has led to a move away from simple diathesis-stress models to more complex models of psychopathology incorporating a focus on gene-environment interactions and epigenetics. Our increased understanding of the way biology encodes the impact of life events on organisms has also generated more sophisticated theoretical models concerning the molecular processes at the interface between "nature" and "nurture." There is also increasing consensus that psychotherapy entails a specific type of learning in the context of an emotional relationship (i.e., the therapeutic relationship) that may also lead to epigenetic modifications across different therapeutic treatment modalities. This paper provides a systematic review of this emerging body of research. It is concluded that, although the evidence is still limited at this stage, extant research does indeed suggest that psychotherapy may be associated with epigenetic changes. Furthermore, it is argued that epigenetic studies may play a key role in the identification of biomarkers implicated in vulnerability for psychopathology, and thus may improve diagnosis and open up future research opportunities regarding the mechanism of action of psychotropic drugs as well as psychotherapy. We review evidence suggesting there may be important individual differences in susceptibility to environmental input, including psychotherapy. In addition, given that there is increasing evidence for the transgenerational transmission of epigenetic modifications in animals and humans exposed to trauma and adversity, epigenetic changes produced by psychotherapy may also potentially be passed on to the next generation, which opens up new perspective for prevention science. We conclude this paper stressing the limitations of current research and by proposing a set of recommendations for future research in this area.
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Patrocinador
dc.description.sponsorship
CONICYT (National Fund for Research and Technology);
FONDECYT: 1150166; PII20150035;
Fund for Innovation and Competitiveness (FIC) of the Chilean Ministry of Economy, Development and Tourism, through the Millennium Scientific Initiative: IS130005;
Scientific Cooperation Program with Latin American Universities (Universidad de Chile);
KU Leuven