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Authordc.contributor.authorUrra, Hery 
Authordc.contributor.authorHenríquez, Daniel R. 
Authordc.contributor.authorCánovas, José 
Authordc.contributor.authorVillarroel Campos, David 
Authordc.contributor.authorCarreras Sureda, Amado 
Authordc.contributor.authorPulgar, Eduardo 
Authordc.contributor.authorMolina, Emiliano 
Authordc.contributor.authorHazari, Younis M. 
Authordc.contributor.authorLimia, Celia M. 
Authordc.contributor.authorÁlvarez Rojas, Sebastián 
Authordc.contributor.authorFigueroa, Ricardo 
Authordc.contributor.authorVidal, René L. 
Authordc.contributor.authorRodríguez, Diego A. 
Authordc.contributor.authorRivera, Claudia A. 
Authordc.contributor.authorCourt, Felipe A. 
Authordc.contributor.authorCouve Correa, Andrés 
Authordc.contributor.authorQi, Ling 
Authordc.contributor.authorChevet, Eric 
Authordc.contributor.authorAkai, Ryoko 
Authordc.contributor.authorIwawaki, Takao 
Authordc.contributor.authorConcha, Miguel L. 
Authordc.contributor.authorGlavic Maurer, Álvaro 
Authordc.contributor.authorGonzález Billault, Christian 
Authordc.contributor.authorHetz Flores, Claudio
Admission datedc.date.accessioned2019-01-13T21:38:39Z
Available datedc.date.available2019-01-13T21:38:39Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationNature Cell Biology | Vol. 20 | August 2018 | 942–953es_ES
Identifierdc.identifier.other10.1038/s41556-018-0141-0
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/159368
Abstractdc.description.abstractMaintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer IRE1 alpha. Filamin A is an actin crosslinking factor involved in cytoskeleton remodelling. We show that IRE1 alpha controls actin cytoskeleton dynamics and affects cell migration upstream of filamin A. The regulation of cytoskeleton dynamics by IRE1 alpha is independent of its canonical role as a UPR mediator, serving instead as a scaffold that recruits and regulates filamin A. Targeting IRE1 alpha expression in mice affected normal brain development, generating a phenotype resembling periventricular heterotopia, a disease linked to the loss of function of filamin A. IRE1 alpha also modulated cell movement and cytoskeleton dynamics in fly and zebrafish models. This study unveils an unanticipated biological function of IRE1 alpha in cell migration, whereby filamin A operates as an interphase between the UPR and the actin cytoskeleton.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherNaturees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceNature Cell Biologyes_ES
Keywordsdc.subjectUnfolded protein responsees_ES
Keywordsdc.subjectEndoplasmic-reticulum stresses_ES
Keywordsdc.subjectRequiring enzyme 1-alphaes_ES
Keywordsdc.subjectIn-Vivoes_ES
Keywordsdc.subjectF-Actines_ES
Keywordsdc.subjectNeuronal migrationes_ES
Keywordsdc.subjectSensor ire1-alphaes_ES
Keywordsdc.subjectCortical-neuronses_ES
Keywordsdc.subjectCerebral-cortexes_ES
Keywordsdc.subjectMessenger-RNAes_ES
Títulodc.titleIRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin Aes_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorlajes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile