Role of dietary alpha- and gamma-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model
Author
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Tapia Opazo, Gladys
Author
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Silva, David
Author
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Romero Palacios, Nalda
Author
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Pettinelli, Paulina
Author
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Dossi, Camila G.
Author
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Miguel, Manuel de
Author
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González Mañán, Daniel Alonso
Admission date
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2019-01-21T19:02:50Z
Available date
dc.date.available
2019-01-21T19:02:50Z
Publication date
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2018
Cita de ítem
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Nutrition 53 (2018) 1–8
es_ES
Identifier
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10.1016/j.nut.2018.01.012
Identifier
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https://repositorio.uchile.cl/handle/2250/159503
Abstract
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Objective: The aim of this study was to evaluate the contribution of tocopherols present in Rosa mosqueta oil (RM) in the prevention of high-fat diet (HFD)-induced alterations.
Methods: Male C57 BL/6 J mice (n = 9/group) were fed for 12 wk and divided into four groups: control (CD; 10% kcal fat, 20% kcal protein, 70% kcal carbohydrates); HFD (60% as fat, 20% kcal protein, 20% kcal carbohydrates); HFD + RM (0.01 mL/g body weight/d); and HFD+ RM - without tocopherols (0.01 mL/g body weight/d). Parameters of obesity, liver steatosis (histology, triacylglycerols content), inflammation (adipose NLRP3 inflammasome, tumor necrosis factor-alpha and interleukin-1 beta expression, hepatic nuclear factor-kappa B) and oxidative stress (hepatic Nrf2 activation, carbonylated proteins) were evaluated.
Results: Liver steatosis, inflammatory, and oxidative stress parameters were significantly (P < 0.05) increased in the HFD + RM - compared with the HFD + RM, with no differences between HFD and HFD + RM.
Conclusion: The present study suggests that alpha- and gamma-tocopherols from RM may have an important role in the prevention of alterations induced by HFD.
es_ES
Patrocinador
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Fondo Nacional de Desarrollo Cientifico y Tecnologico-FONDECYT (Chile)
1140547
11150685