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Authordc.contributor.authorTapia Opazo, Gladys 
Authordc.contributor.authorSilva, David 
Authordc.contributor.authorRomero Palacios, Nalda 
Authordc.contributor.authorPettinelli, Paulina 
Authordc.contributor.authorDossi, Camila G. 
Authordc.contributor.authorMiguel, Manuel de 
Authordc.contributor.authorGonzález Mañán, Daniel Alonso 
Admission datedc.date.accessioned2019-01-21T19:02:50Z
Available datedc.date.available2019-01-21T19:02:50Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationNutrition 53 (2018) 1–8es_ES
Identifierdc.identifier.other10.1016/j.nut.2018.01.012
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/159503
Abstractdc.description.abstractObjective: The aim of this study was to evaluate the contribution of tocopherols present in Rosa mosqueta oil (RM) in the prevention of high-fat diet (HFD)-induced alterations. Methods: Male C57 BL/6 J mice (n = 9/group) were fed for 12 wk and divided into four groups: control (CD; 10% kcal fat, 20% kcal protein, 70% kcal carbohydrates); HFD (60% as fat, 20% kcal protein, 20% kcal carbohydrates); HFD + RM (0.01 mL/g body weight/d); and HFD+ RM - without tocopherols (0.01 mL/g body weight/d). Parameters of obesity, liver steatosis (histology, triacylglycerols content), inflammation (adipose NLRP3 inflammasome, tumor necrosis factor-alpha and interleukin-1 beta expression, hepatic nuclear factor-kappa B) and oxidative stress (hepatic Nrf2 activation, carbonylated proteins) were evaluated. Results: Liver steatosis, inflammatory, and oxidative stress parameters were significantly (P < 0.05) increased in the HFD + RM - compared with the HFD + RM, with no differences between HFD and HFD + RM. Conclusion: The present study suggests that alpha- and gamma-tocopherols from RM may have an important role in the prevention of alterations induced by HFD.es_ES
Patrocinadordc.description.sponsorshipFondo Nacional de Desarrollo Cientifico y Tecnologico-FONDECYT (Chile) 1140547 11150685es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceNutritiones_ES
Keywordsdc.subjectTocopheroles_ES
Keywordsdc.subjectRosa mosquetaes_ES
Keywordsdc.subjectObesityes_ES
Keywordsdc.subjectInflammationes_ES
Keywordsdc.subjectOxidative stresses_ES
Keywordsdc.subjectLiveres_ES
Títulodc.titleRole of dietary alpha- and gamma-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine modeles_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorlajes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile