Author | dc.contributor.author | González Martín, G. | |
Author | dc.contributor.author | Bravo, Roberto | |
Author | dc.contributor.author | Ibarra, Germán | |
Author | dc.contributor.author | Arancibia, Verónica | |
Admission date | dc.date.accessioned | 2019-01-29T12:39:46Z | |
Available date | dc.date.available | 2019-01-29T12:39:46Z | |
Publication date | dc.date.issued | 1983 | |
Cita de ítem | dc.identifier.citation | International Journal of Clinical Pharmacology Therapy and Toxicology, Volumen 21, Issue 12, 1983, Pages 598-601 | |
Identifier | dc.identifier.issn | 01744879 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/159635 | |
Abstract | dc.description.abstract | The pharmacokinetic disposition of furosemide has been investigated in seven children with nephrotic syndrome and in eight control children. Furosemide in plasma was analyzed by spectrofluorometry. After a single intravenous dose of furosemide (1 mg/kg body wt.) the nephrotic children showed lower initial plasma concentrations because of the larger volume of distribution. The mean half-life of furosemide in nephrotic children (38.5 ± 7.8 min) was significantly longer than in the control group (28.0 ± 7.7 min). The two groups did not differ in the body clearance of total furosemide. The average serum clearance was 4.95 ± 1.7 ml/min/kg body wt. in the control group and 5.10 ± 1.4 ml/min/kg body wt. in the nephrotic children. There was a significant reduction in urine sodium and distribution volume, whereas potassium excretion remained unchanged. | |
Lenguage | dc.language.iso | en | |
Source | dc.source | International Journal of Clinical Pharmacology Therapy and Toxicology | |
Keywords | dc.subject | Pharmacology (medical) | |
Keywords | dc.subject | Toxicology | |
Título | dc.title | Clinical pharmacokinetics of furosemide in children with nephrotic syndrome | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | |
Cataloguer | uchile.catalogador | jmm | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |