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Authordc.contributor.authorPereda, J. 
Authordc.contributor.authorCroxatto, H. B. 
Admission datedc.date.accessioned2019-01-29T12:39:57Z
Available datedc.date.available2019-01-29T12:39:57Z
Publication datedc.date.issued1992
Cita de ítemdc.identifier.citationAnnals of the Academy of Medicine Singapore, Volumen 21, Issue 4, 1992, Pages 480-488
Identifierdc.identifier.issn03044602
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/159692
Abstractdc.description.abstractThe ultrastructure of a 2-cell, 4-cell, 7-cell and 16-cell human embryos fertilised and developed in vivo were compared using transmission electron microscopy. Among the structures which exhibited more notable changes throughout these developmental stages, were the mitochondria, ribosomes, nuclear envelope and nucleolus. Mitochondria which were initially round, dense with cristae oriented parallel to the surface changed to oval with less dense mitochondrial matrix and with cristae perpendicular to the mitochondrial membrane. Ribosomes and polyribosomes decreased in amount from 2 to 7-cell stages and increased again at the 16-cell stage. The nuclear envelope exhibited intense blebbing activity at the 4-cell stage, less at 7 and none at 16. The nucleolus initially very dense was progressively infiltrated by chromatin, became reticular at the 7-cell stage and appeared fully mature at the 16-cell stage. This study discloses structural details of human preimplantation embryos which may be of interest in the assessment of comparable material obtained in vitro. Some unique features that may have bearing on the ontogenesis of cell organelles and cell differentiation are discussed.
Lenguagedc.language.isoen
Sourcedc.sourceAnnals of the Academy of Medicine Singapore
Keywordsdc.subjectMedicine (all)
Títulodc.titleHuman preimplantation development in vivo: ultrastructural observations.
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso a solo metadatos
Catalogueruchile.catalogadorjmm
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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