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Autordc.contributor.authorFernández Arancibia, Virginia 
Autordc.contributor.authorMassa, Laura 
Autordc.contributor.authorQuiñones Sepúlveda, Luis 
Autordc.contributor.authorSimon-Giavarotti, Karin A. 
Autordc.contributor.authorGiavarotti, Leandro 
Autordc.contributor.authorD'Almeida, Vânia 
Autordc.contributor.authorAzzalis, Ligia A. 
Autordc.contributor.authorJunqueira, Virginia B.C. 
Autordc.contributor.authorVidela Cabrera, Luis 
Fecha ingresodc.date.accessioned2019-01-29T13:47:50Z
Fecha disponibledc.date.available2019-01-29T13:47:50Z
Fecha de publicacióndc.date.issued2003
Cita de ítemdc.identifier.citationBiological Research, Volumen 36, Issue 3-4, 2003, Pages 359-365
Identificadordc.identifier.issn07169760
Identificadordc.identifier.other10.4067/S0716-97602003000300007
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/159827
Resumendc.description.abstractLiver microsomal cytochrome P4502E1-dependent p-nitrophenol (PNP) hydroxylation and expression of cytochrome P4502E1 were studied in rats subjected to gamma-hexachlorocyclohexane (HCCH) or L-3,3,5-triiodothyronine (T3) administration as a possible mechanism contributing to superoxide radical (O2.-) generation. HCCH treatment (a single dose of 40 mg/kg body wt) produced a 43% increase in the content of total cytochrome P450, whereas T3 (daily doses of 0.1 mg/kg body wt for two consecutive days) led to a 37% decrease. NADPH-dependent O2.- generation was elevated by HCCH and T3, expressed as either per mg of protein or per nmol of cytochrome P450, with a 135% enhancement in the O2.- production/superoxide dismutase (SOD) activity ratios being observed in both conditions. This was partly due to depression of SOD activity. Concomitantly, the molecular activity of NADPH-cytochrome p450 reductase was enhanced by 90 and 69% by HCCH and T3, respectively. In these conditions, microsomal PNP hydroxylation showed increases of 58 and 45% in HCCH- and T3-treated rats over control values, respectively, with a parallel 31% (HCCH) and 41% (T3) enhancement in the content of cytochrome P4502E1 assessed by western immunoblotting. We conclude that HCCH and T3 enhance the expression and activity of cytochrome P4502E1 and that of NADPH-cytochrome P450 reductase in rat liver, regardless of the changes in total cytochrome P450 content, representing major contributory mechanisms to microsomal NADPH-dependent O2.- generation.
Idiomadc.language.isoen
Publicadordc.publisherSociety of Biology of Chile
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Fuentedc.sourceBiological Research
Palabras clavesdc.subjectCytochrome P4502E1
Palabras clavesdc.subjectL-3,3′,5-triiodothyronine
Palabras clavesdc.subjectRat liver
Palabras clavesdc.subjectSuperoxide radical
Palabras clavesdc.subjectγ-hexachlorocyclohexane
Títulodc.titleEffects of γ-hexachlorocyclohexane and L-3,3′,5-triiodothyronine on rat liver cytochrome P4502E1-dependent activity and content in relation to microsomal superoxide radical generation
Tipo de documentodc.typeArtículo de revista
Catalogadoruchile.catalogadorjmm
Indizaciónuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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