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Authordc.contributor.authorCampo, Andrea del 
Authordc.contributor.authorRoldán, Juan 
Authordc.contributor.authorVerdejo, Hugo E. 
Authordc.contributor.authorZalaquett Sepúlveda, Ricardo 
Authordc.contributor.authorBecerra, Elia 
Authordc.contributor.authorNavarro Márquez, Mario 
Authordc.contributor.authorMellado, Rosemarie 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorCorbalán, Ramón 
Authordc.contributor.authorGarcía Nannig, Lorena 
Authordc.contributor.authorChiong Lay, Mario 
Admission datedc.date.accessioned2019-01-29T14:12:23Z
Available datedc.date.available2019-01-29T14:12:23Z
Publication datedc.date.issued2017
Cita de ítemdc.identifier.citationJournal of Cardiology 70 (2017) 578–583
Identifierdc.identifier.issn18764738
Identifierdc.identifier.issn09145087
Identifierdc.identifier.other10.1016/j.jjcc.2017.03.011
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/160195
Abstractdc.description.abstractBackground: Increased inflammation biomarkers plasma levels, including C-reactive protein (CRP), have been associated with the initiation and perpetuation of atrial fibrillation (AF). However, it is not known whether an increased CRP plasma level, without concomitant inflammation, is sufficient to induce AF. We investigated whether higher CRP plasma levels, determined by the presence of +219G>A CRP gene polymorphism, is associated with an increased risk of post-operative AF. Methods: One hundred and fifteen adult patients submitted to elective coronary surgery were genotyped for the CRP +219G>A polymorphism. CRP plasma levels were determined by enzyme-linked immunosorbent assay. Results: CRP plasma levels before surgery were higher in GG than in GA + AA patients (3.4 +/- 3.1 vs. 1.7 +/- 1.8, p < 0.015). Thirteen percent of the patients presented post-operative AF. Despite the positive correlation between the polymorphism and CRP levels, there was no significant difference in the occurrence of post-operative AF between the different genotypes. Conclusions: These results suggest that increased CRP plasma levels that are not associated with an inflammatory process are not sufficient to trigger AF after cardiac surgery.
Lenguagedc.language.isoen
Publisherdc.publisherElsevier
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceJournal of Cardiology
Keywordsdc.subjectAtrial fibrillation
Keywordsdc.subjectC-reactive protein
Keywordsdc.subjectGene polymorphism
Keywordsdc.subjectInflammation
Títulodc.titleIncreased C-reactive protein plasma levels are not involved in the onset of post-operative atrial fibrillation
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorlaj
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile