Interrelationships among serum thyroxine, triiodothyronine, reverse triiodothyronine, and thyroid-stimulating hormone in iodine-deficient pregnant women and their offspring: Effects of iodine supplementation
Author
dc.contributor.author
Silva, J. E.
Author
dc.contributor.author
Silva, Sergio
Admission date
dc.date.accessioned
2019-01-29T14:20:29Z
Available date
dc.date.available
2019-01-29T14:20:29Z
Publication date
dc.date.issued
1981
Cita de ítem
dc.identifier.citation
Journal of Clinical Endocrinology and Metabolism, Volumen 52, Issue 4, 2018, Pages 671-677
Identifier
dc.identifier.issn
19457197
Identifier
dc.identifier.issn
0021972X
Identifier
dc.identifier.other
10.1210/jcem-52-4-671
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/160418
Abstract
dc.description.abstract
Adaptation to iodine deficiency (ID) requires changes in thyroid and pituitary function that have been well characterized in animals. The present studies were undertaken to analyze the relationships between serum thyroid hormones and TSH concentrations in iodine-deficient pregnantwomen as well as their newborns. The broad range of iodine intake of the population studied, from very low to adequate, allowed us to describe quantitatively the relationships among iodine intake, thyroid hormones, and TSH. The interpretation of the data was supported by the effects that iodinesupplementation had on these various hormones and is consistent with animal observations. About 250 pregnant women from an iodine-deficient area were studied. Fifty percent had a urinary iodine excretion of 50 μg creatinine (cr) or less; 25% had 50∓100 ug I/g-cr, and about 20% had 100∓200 ug I/g cr. Baseline serum hormone concentrations on first examination (mean ± SD) were: T4, 8.0± 0.7 jug⁄dl; T3 = 179 ° 45ng⁄dl; rT3,
Interrelationships among serum thyroxine, triiodothyronine, reverse triiodothyronine, and thyroid-stimulating hormone in iodine-deficient pregnant women and their offspring: Effects of iodine supplementation