Temporal summation in rat prefrontal pyramidal cells. Differential effects of pre- and postsynaptic neurochemical manipulations

Abstract

The influence of both reserpine-induced depletion of catecolamines and chlorpromazine-induced blockade of dopamine receptors on integrative properties of rats prefrontal pyramidal cells was studied by evocating threshold direct cortical responses with different trains of electrical pulses. Catecholamine depletion results in increased pulse train stimulating currents for eliciting threshold cortical responses, whereas chlorpromazine blockade of dopamine receptors results in higher time constants characterizing postsynaptic temporal summation. It is suggested that the leaky-integrator neuron model may be a discriminating paradigm for detecting electrophysiologically the pre- or postsynaptic level of occurrence of some synaptic disorders.