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Authordc.contributor.authorReyes, Consuelo 
Authordc.contributor.authorBorriero, Laura 
Authordc.contributor.authorBenos, Dale J. 
Admission datedc.date.accessioned2019-01-29T14:47:46Z
Available datedc.date.available2019-01-29T14:47:46Z
Publication datedc.date.issued1988
Cita de ítemdc.identifier.citationAmerican Journal of Physiology - Cell Physiology, Volumen 254, Issue 4, 1988
Identifierdc.identifier.issn00029513
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/160610
Abstractdc.description.abstractRat spermatogenic cells have glycolytic rates of 124 ± 36 nmol lactate · mg protein -1 · h-1. Maximum glycolytic rates in the absence of oxidative phosphorylation do not exceed the basal rates by>40%. From the rates of oxygen consumption and lactate production it can be calculated that <8% of the total ATP produced by spermatogenic cells is provided by glycolysis. These properties of spermatogenic cells would render them highly susceptible to cytotoxicity due to the action of agents like gossypol that impair mitochondrial oxidative phosphorylation or to conditions that produce testicular hypoxia. The main effect of gossypol on spermatogenic cell energy metabolism is to uncouple mitochondrial oxidative phosphorylation. In the absence of glucose, this uncoupling action of gossypol would change the NAD+/NADH redox coupling and, consequently, could modify metabolic fluxes through the lactic dehydrogenase catalyzed reaction.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAmerican Journal of Physiology - Cell Physiology
Keywordsdc.subjectPhysiology
Keywordsdc.subjectCell Biology
Títulodc.titleA bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorlaj
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile