Influence of hormones on DNA synthesis of breast tumors in culture
Author
dc.contributor.author
Calaf, Gloria
Author
dc.contributor.author
Garrido, Fernando
Author
dc.contributor.author
Moyano, Carlos
Author
dc.contributor.author
Rodríguez, Roberto
Admission date
dc.date.accessioned
2019-01-29T14:47:47Z
Available date
dc.date.available
2019-01-29T14:47:47Z
Publication date
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1986
Cita de ítem
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Breast Cancer Research and Treatment, Volumen 8, Issue 3, 2018, Pages 223-232
Identifier
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01676806
Identifier
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15737217
Identifier
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10.1007/BF01807335
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/160613
Abstract
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Tissue culture techniques have been developed for studying the influence of hormones on human breast tissues. The present study demonstrated that estrogen induced a highly significant increase in3H-thymidine incorporation into DNA and labelling index of ductal epithelium of fibrocystic disease; there was no effect of progesterone, either alone or in combination with ovine prolactin, on benign lesions. Estrogen stimulated certain malignant tumors derived from postmenopausal women. These studies also showed that there was an inhibitory effect of3H-thymidine incorporation into DNA by the effect of progesterone on malignant lesions. When menopausal status was considered, it was found that DNA synthesis was significantly higher in the presence of insulin and hydrocortisone in malignant tumors derived from premenopausal women than from postmenopausal women, or than in benign lesions. Thus, the present findings may provide evidence that specific activity may be an important measurement for br