Treatment of leiomyomata uteri with D-Trp6-luteinizing hormone-releasing hormone
Author
dc.contributor.author
Perl, V.
Author
dc.contributor.author
Marquez, J.
Author
dc.contributor.author
Schally, A. V.
Author
dc.contributor.author
Comaru Schally, A. M.
Author
dc.contributor.author
Leal, G.
Author
dc.contributor.author
Zacharias, S.
Author
dc.contributor.author
Gómez Lira, C.
Admission date
dc.date.accessioned
2019-01-29T14:47:49Z
Available date
dc.date.available
2019-01-29T14:47:49Z
Publication date
dc.date.issued
1987
Cita de ítem
dc.identifier.citation
Fertility and Sterility, Volumen 48, Issue 3, 2018, Pages 383-389
Identifier
dc.identifier.issn
00150282
Identifier
dc.identifier.other
10.1016/S0015-0282(16)59403-5
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/160628
Abstract
dc.description.abstract
Suppression of the secretion of gonadal steroids by chronic administration of a superactive agonist of luteinizing hormone-releasing hormone (LH-RH) was used for treatment of leiomyomata uteri. Ten menstruating women, presenting with a total of 20 uterine leiomyomas, were treated for 3 months with daily subcutaneous injections of D-Trp6-LH-RH. Serum estradiol (E2) levels were suppressed rapidly in five patients and were decreased in other patients. At the end of therapy, leiomyomas regressed completely in three patients, while five patients showed a decrease of more than 40% in the volume of leiomyomas. The reduction in tumor size was correlated with the rapidity of the fall in serum E2 levels. In one patient, the leiomyomata increased in size during treatment, and one woman had a poor clinical response. The agonist was well tolerated and few side effects were observed. Therapy with LH-RH agonists offers an alternative in the management of some uterine leiomyomas.