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Authordc.contributor.authorJunqueira, Virginia 
Authordc.contributor.authorSimizu, Kiyoko 
Authordc.contributor.authorVidela Cabrera, Luis
Authordc.contributor.authorSilvia, Silvia B. 
Cita de ítemdc.identifier.citationToxicology, Volumen 41, Issue 2, 2018, Pages 193-204
Abstractdc.description.abstractThe administration of single i.p. doses of lindane (20, 40, 60 and 80 mg/kg) to rats produced a progressive increase in the liver microsomal content of cytochrome P-450 and in the rate of superoxide anion generation, as measured by adrenochrome formation. A dose-dependent increase in lipid peroxidation of liver homogenates, assessed by measuring thiobarbituric acid reactants, was also found. Lindane treatment did not alter the activity of liver glucose-6-phosphate dehydrogenase, glutathione reductase or glutathione peroxidase, while that of superoxide dismutase and catalase was significantly reduced. These changes were accompanied by a progressive liver steatosis. The collected metabolic data were interpreted in terms of a causal relationship between an increase in superoxide radical generation, secondary to cytochrome P-450 induction and a resulting increase in lipid peroxidation. The decrease in superoxide dismutase and catalase activities is likely to contribute to the increased lev
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
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Keywordsdc.subjectHepatic cytochrome P-450
Keywordsdc.subjectLipid peroxidation
Keywordsdc.subjectLiver steatosis
Keywordsdc.subjectSuperoxide anion production
Títulodc.titleDose-dependent study of the effects of acute lindane administration on rat liver superoxide anion production, antiooidant enzyme activities and lipid peroxidation
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile