A quantum-chemical and experimental study of the hallucinogen (±)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON)
| Author | dc.contributor.author | Gómez Jeria, Juan | |
| Author | dc.contributor.author | Cassels Niven, Bruce | |
| Author | dc.contributor.author | Saavedra Aguilar, Juan Carlos | |
| Admission date | dc.date.accessioned | 2019-01-29T14:47:56Z | |
| Available date | dc.date.available | 2019-01-29T14:47:56Z | |
| Publication date | dc.date.issued | 1987 | |
| Cita de ítem | dc.identifier.citation | European Journal of Medicinal Chemistry, Volumen 22, Issue 5, 2018, Pages 433-437 | |
| Identifier | dc.identifier.issn | 17683254 | |
| Identifier | dc.identifier.issn | 02235234 | |
| Identifier | dc.identifier.other | 10.1016/0223-5234(87)90032-8 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/160667 | |
| Abstract | dc.description.abstract | The electronic structure of 1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON) was calculated at the CNDO/2 level, and the racemic compound was synthesized and found to be hallucinogenic at doses of 4 mg. DON differs from its similarly active congeners in that a hydrophilic nitro group replaces lipophilic substituents at C-4 of the benzene ring. The implications for the mechanism of serotonin receptor binding of these drugs are discussed. © 1987. | |
| Lenguage | dc.language.iso | en | |
| Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| Source | dc.source | European Journal of Medicinal Chemistry | |
| Keywords | dc.subject | atomic charge | |
| Keywords | dc.subject | CNDO/2 | |
| Keywords | dc.subject | DON | |
| Keywords | dc.subject | electrophilic superdelocalizability | |
| Keywords | dc.subject | frontier molecular orbitals | |
| Keywords | dc.subject | hallucinogenic potency | |
| Keywords | dc.subject | lipophilicity | |
| Keywords | dc.subject | serotonin receptor affinity | |
| Título | dc.title | A quantum-chemical and experimental study of the hallucinogen (±)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON) | |
| Document type | dc.type | Artículo de revista | |
| Cataloguer | uchile.catalogador | SCOPUS | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
| uchile.cosecha | uchile.cosecha | SI |
Files in this item
This item appears in the following Collection(s)
-
Artículos de revistas
Artículos de revistas
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile