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Authordc.contributor.authorReyes Reyes, Consuelo 
Authordc.contributor.authorBenos, 
Admission datedc.date.accessioned2019-01-29T14:48:02Z
Available datedc.date.available2019-01-29T14:48:02Z
Publication datedc.date.issued1988
Cita de ítemdc.identifier.citationAmerican Journal of Physiology - Cell Physiology, Volumen 254, Issue 4, 2018,
Identifierdc.identifier.issn00029513
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/160705
Abstractdc.description.abstractA comparative study of gossypol uncoupling of rat spermatogenic and liver cells shows that spermatogenic cells metabolizing pyruvate are two to three times more sensitive to gossypol uncoupling than either spermatogenic cells metabolizing glucose or liver cells metabolizing pyruvate or glucose. Direct measurements of in situ rat liver and spermatogenic cell mitochondrial respiration indicate that the pyruvate dependence of the gossypol uncoupling appears to be located in the spermatogenic cell mitochondria. A different type of mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone does not present the substrate-dependent uncoupling effect. This special interaction between spermatogenic cell pyruvate metabolism and gossypol uncoupling confers specificity to a bioenergetic model of gossypol action.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAmerican Journal of Physiology - Cell Physiology
Keywordsdc.subjectPhysiology
Keywordsdc.subjectCell Biology
Títulodc.titleSpecificity of gossypol uncoupling: a comparative study of liver and spermatogenic cells
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile