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Authordc.contributor.authorHidalgo Tapia, María Cecilia 
Authordc.contributor.authorJaimovich Pérez, Enrique 
Cita de ítemdc.identifier.citationJournal of Bioenergetics and Biomembranes, Volumen 21, Issue 2, 2018, Pages 267-281
Abstractdc.description.abstractThe role of inositol trisphosphate as a chemical messenger in excitation-contraction coupling is discussed, both in terms of positive and negative results. The evidence presented includes experiments on the effect of inositol trisphosphate in intact and skinned fibers, in calcium release from isolated sarcoplasmic reticulum vesicles, in activation of single calcium release channels incorporated in planar bilayers, and biochemical experiments that have established the presence of all the intermediate steps involved in the metabolism of phosphoinositides, both in intact muscle and in isolated membranes. From these results, it is clear that a role for inositol triphosphate in skeletal muscle function is highly likely; whether this molecule is the physiological messenger in excitation-contraction coupling remains to be established. © 1989 Plenum Publishing Corporation.
Publisherdc.publisherKluwer Academic Publishers-Plenum Publishers
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Bioenergetics and Biomembranes
Keywordsdc.subjectCalcium channels
Keywordsdc.subjectexcitation-contraction coupling
Keywordsdc.subjectinositol trisphosphate
Keywordsdc.subjectphosphoinositide metabolism
Keywordsdc.subjectsarcoplasmic reticulum
Keywordsdc.subjectskeletal muscle
Keywordsdc.subjectskinned fibers
Keywordsdc.subjecttransverse tubules
Títulodc.titleInositol trisphosphate and excitation-contraction coupling in skeletal muscle
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile