Metabolic activation: a biological mechanism that augments the toxicity of xenobiotics Activación metabólica: un mecanismo biológico que aumenta la toxicidad de los xenobióticos.

Author	dc.contributor.author	Valenzuela,
Admission date	dc.date.accessioned	2019-01-29T14:49:26Z
Available date	dc.date.available	2019-01-29T14:49:26Z
Publication date	dc.date.issued	1990
Cita de ítem	dc.identifier.citation	Revista medica de Chile, Volumen 118, Issue 9, 2018, Pages 1028-1034
Identifier	dc.identifier.issn	00349887
Identifier	dc.identifier.uri	https://repositorio.uchile.cl/handle/2250/160860
Abstract	dc.description.abstract	Metabolic changes sustained by foreign substances (biotransformation), xenobiotics, may not always lead to a decreased toxicity from these substances. Metabolic activation, a process that may increase toxicity and chemical reactivity of these substances, may occur at the first or second phase of biotransformation. Electrophiles of nucleophiles may be formed. Lipoperoxidation by free oxygen radicals may thus follow. Details of these processes are discussed in the paper.
Lenguage	dc.language.iso	en
Type of license	dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License	dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source	dc.source	Revista medica de Chile
Keywords	dc.subject	Medicine (all)
Título	dc.title	Metabolic activation: a biological mechanism that augments the toxicity of xenobiotics Activación metabólica: un mecanismo biológico que aumenta la toxicidad de los xenobióticos.
Document type	dc.type	Artículo de revista
Cataloguer	uchile.catalogador	SCOPUS
Indexation	uchile.index	Artículo de publicación SCOPUS
uchile.cosecha	uchile.cosecha	SI

Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile