The pharmacokinetic bases of management with drugs having a narrow therapeutic range Bases farmacocinéticas del manejo de fármacos de estrecho rango terapéutico.

Abstract

The growing tendency to measure blood drug levels of patients with different diseases call for understanding of pharmacokinetic basis of this diagnostic tool. The article is focused on the pharmacological basis of drug use, as well as on factors involved in pharmacokinetic variations related to clinical picture and biological condition of the patient. Processes regulating drug entry and drug release to and from the general circulation are discussed in the context of disease pathophysiology.