Microalbuminuria in insulin-dependent diabetics: the prevention of diabetic nephropathy Microalbuminuria en diabéticos insulinodependientes: prevención de la nefropatía diabética.
Author
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Durruty,
Author
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Krause,
Author
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Pérez,
Author
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García de los Ríos,
Author
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López López, J. A.
Author
dc.contributor.author
Durruty,
Admission date
dc.date.accessioned
2019-01-29T14:49:28Z
Available date
dc.date.available
2019-01-29T14:49:28Z
Publication date
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1990
Cita de ítem
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Revista medica de Chile, Volumen 118, Issue 12, 2018, Pages 1319-1325
Identifier
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00349887
Identifier
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https://repositorio.uchile.cl/handle/2250/160877
Abstract
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We evaluated the effects of angiotensin converting enzyme inhibition upon the urinary excretion of albumin in 36 insulin dependent normotensive diabetic patients with adequate metabolic control and no evidence of renal failure. 19 subjects had normal levels of albumin excretion (< 30 mg/24 h) and 17 showed microalbuminuria from 30 to 300 mg/24 h. Half of the patients were randomly selected in each group to receive enalapril, 5 mg/day. A progressive decrease in albumin excretion levels was observed for both enalapril treated subgroups, from 18.9 +/- 8.3 to 8.1 +/- 2.7 mg/24 h (normoalbuminurics) and from 73.1 +/- 25.0 to 40.1 +/- 26.3 mg/24 h (microalbuminurics). In contrast, an increase in albumin excretion from 19.4 +/- 6.8 to 29.4 +/- 14.2 mg/24 h was observed in non treated normoalbuminuric patients. Untreated patients with microalbuminuria remained with stable albumin excretion levels (67.4 +/- 39 to 64.8 +/- 23.4 mg/24 h). Enalapril treatment was associated to a significant (p < 0
Microalbuminuria in insulin-dependent diabetics: the prevention of diabetic nephropathy Microalbuminuria en diabéticos insulinodependientes: prevención de la nefropatía diabética.