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Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorYudelevich, J. 
Authordc.contributor.authorSquella Serrano, Juan
Authordc.contributor.authorSpeisky Cosoy, Hernán 
Cita de ítemdc.identifier.citationAlcohol and Alcoholism, Volumen 26, Issue 2, 2018, Pages 139-146
Abstractdc.description.abstractAcetaldehyde, at concentrations occurring in vivo was found to avidly react in vitro with several clinically relevant drugs. The greatest reactivity was observed for the hydrazine and hydrazide-containing drugs, hydralazine and isoniazid, respectively. Substantial reactivity was also evidenced for the amine-containing penicillins cyclacillin and ampicillin and for the cephalosporins cephalexin, cephradroxyl and cephradine. However, the virtual lack of reactivity of the amine-containing penicillanic and cephalosporanic acids reveals a major role of the acyl groups of these antibiotics in their reactivity towards acetaldehyde. The presence of moieties which increase the electron density of the amine group appears to favour the molecule reactivity. Amongst several phenylethylamines tested, dopamine and noradrenaline were the most active in forming adducts with acetaldehyde. It is suggested that in vitro binding of acetaldehyde to the above-mentioned drugs could lead in vivo to decreased d
Publisherdc.publisherOxford University Press
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceAlcohol and Alcoholism
Keywordsdc.subjectMedicine (miscellaneous)
Keywordsdc.subjectPsychiatry and Mental Health
Títulodc.titleDrug-acetaldehyde interactions during ethanol metabolism in vitro
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile