Drug-acetaldehyde interactions during ethanol metabolism in vitro
Author
dc.contributor.author
Núñez Vergara, Luis
Author
dc.contributor.author
Yudelevich, J.
Author
dc.contributor.author
Squella Serrano, Juan
Author
dc.contributor.author
Speisky Cosoy, Hernán
Admission date
dc.date.accessioned
2019-01-29T14:49:31Z
Available date
dc.date.available
2019-01-29T14:49:31Z
Publication date
dc.date.issued
1991
Cita de ítem
dc.identifier.citation
Alcohol and Alcoholism, Volumen 26, Issue 2, 2018, Pages 139-146
Identifier
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07350414
Identifier
dc.identifier.other
10.1093/oxfordjournals.alcalc.a045094
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/160894
Abstract
dc.description.abstract
Acetaldehyde, at concentrations occurring in vivo was found to avidly react in vitro with several clinically relevant drugs. The greatest reactivity was observed for the hydrazine and hydrazide-containing drugs, hydralazine and isoniazid, respectively. Substantial reactivity was also evidenced for the amine-containing penicillins cyclacillin and ampicillin and for the cephalosporins cephalexin, cephradroxyl and cephradine. However, the virtual lack of reactivity of the amine-containing penicillanic and cephalosporanic acids reveals a major role of the acyl groups of these antibiotics in their reactivity towards acetaldehyde. The presence of moieties which increase the electron density of the amine group appears to favour the molecule reactivity. Amongst several phenylethylamines tested, dopamine and noradrenaline were the most active in forming adducts with acetaldehyde. It is suggested that in vitro binding of acetaldehyde to the above-mentioned drugs could lead in vivo to decreased d