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Authordc.contributor.authorSpeisky Cosoy, Hernán 
Authordc.contributor.authorCassels Niven, Bruce
Authordc.contributor.authorLissi Gervaso, Eduardo A. 
Authordc.contributor.authorVidela Cabrera, Luis
Admission datedc.date.accessioned2019-01-29T14:49:31Z
Available datedc.date.available2019-01-29T14:49:31Z
Publication datedc.date.issued1991
Cita de ítemdc.identifier.citationBiochemical Pharmacology, Volumen 41, Issue 11, 2018, Pages 1575-1581
Identifierdc.identifier.issn00062952
Identifierdc.identifier.other10.1016/0006-2952(91)90156-Y
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/160896
Abstractdc.description.abstractBoldine, in low micromolar concentrations, was able to prevent brain homogenate autooxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation of lysozyme. These results are indicative of a high reactivity of boldine towards free radicals. The analysis of the boldine effect as a function of incubation times suggests that a metabolite resulting from the interaction of boldine with free radicals also exhibits antioxidant activity, being more efficient than boldine in brain homogenate auto-oxidation and less efficient in lysozyme protection experiments. This behavior may be accounted for in terms of the relative location of the scavengers needed to afford maximal protection. © 1991.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiochemical Pharmacology
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectPharmacology
Títulodc.titleAntioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile