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Authordc.contributor.authorCarrión, Yasna 
Authordc.contributor.authorFernández Arancibia, Virginia 
Authordc.contributor.authorVidela Cabrera, Luis
Cita de ítemdc.identifier.citationBiochemical Pharmacology, Volumen 45, Issue 12, 2018, Pages 2527-2535
Abstractdc.description.abstractThe effect of thyroid hormone administration on liver glutathione (GSH) content and γ-glutamyltransferase activity in the isolated perfused liver was studied for a period of 1-7 days in fed rats following a single dose of 0.1 mg 3,5,3'-l-triiodothyronine (T3)/kg. T3 elicited an early and transient calorigenic response, together with GSH depletion at 1 day after treatment. Recovery of hepatic GSH content and enhancement in total basolateral γ-glutamyltransferase activity occurred in parallel 2-3 days after T3 treatment, parameters that were normalized in the 4- to 7-day time interval studied. The increase in total basolateral γ-glutamyltransferase activity by T3 at early times after treatment was due mainly to increments in its transpeptidation mechanism, and was characterized by increments in the apparent maximum velocities without changes in the apparent Michaelis constant (Km) for the substrate γ-glutamyl-p-nitroanilide. Data presented suggest that the elevation in sinusoidal γ-gluta
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
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Sourcedc.sourceBiochemical Pharmacology
Títulodc.titleInfluence of thyroid hormone administration on hepatic glutathione content and basolateral γ-glutamyltransferase ectoactivity in the isolated perfused rat liver
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile