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Authordc.contributor.authorVidela Cabrera, Luis
Authordc.contributor.authorCorrea, Loreto 
Authordc.contributor.authorRivera, Marcela 
Authordc.contributor.authorSir Petermann, Teresa 
Cita de ítemdc.identifier.citationFree Radical Biology & Medicine, Vol. 14, pp. 669-675, 1993
Abstractdc.description.abstractLuminol-amplified CL of whole blood phagocytes was studied in rats given 3 consecutive doses of 0.1 mg L-triiodothyronine T3/kg or in hyperthyroid patients, after stimulation by zymosan. In both cases, CL was significantly increased, an effect which was produced independently of the opsonization of the zymosan particles and markedly inhibited by azide. The in vitro addition ofT3 or L-thyroxine (T4) to whole blood phagocytes from normal rats did not modify the opsonized zymosan-dependent CL, when assayed at the concentrations found in euthyroid subjects or in hyperthyroid patients. Administration of propylthiouracil (400 mg/day for 2-3 months) to hyperthyroid patients reduced the CL response observed prior to treatment, to values comparable to those found in the euthyroid group. These data indicate that hyperthyroidism elicits an enhanced respiratory burst activity of whole blood phagocytes, probably related to adaptive changes induced by thyroid hormone on the mieloperoxidase-H202 system, rather than to direct actions of the hormone molecule or changes in the opsonic capacity of plasma.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceFree Radical Biology and Medicine
Keywordsdc.subjectFree radicals
Keywordsdc.subjectRespiratory burst activity
Keywordsdc.subjectWhole blood phagocytes
Títulodc.titleZymosan-induced luminol-amplified chemiluminescence of whole blood phagocytes in experimental and human hyperthyroidism
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile