Show simple item record

Authordc.contributor.authorQuintanilla González, María Elena 
Authordc.contributor.authorTampier de Jong, Lutske 
Admission datedc.date.accessioned2019-01-29T14:52:18Z
Available datedc.date.available2019-01-29T14:52:18Z
Publication datedc.date.issued1992
Cita de ítemdc.identifier.citationAlcohol, Volumen 9, Issue 5, 2018, Pages 375-380
Identifierdc.identifier.issn07418329
Identifierdc.identifier.other10.1016/0741-8329(92)90035-9
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/161078
Abstractdc.description.abstractThe effect of a chronic ethanol consumption by forcing rats to drink a 20% v/v ethanol solution as sole drinking fluid, for 3 months, was evaluated on: liver and brain mitochondrial function, the capacity of isolated mitochondria to oxidize acetaldehyde, as well as on the low Km mitochondrial AlDH activity, in rats. The O2 uptake by liver and brain mitochondria in the presence of glutamate + malate, succinate or ascorbate + TMPD, was measured polarographically with a Clark electrode. Acetaldehyde oxidation was measured by the disappearance rate in presence of the intact or disrupted mitochondria (AlDH activity) by gas chromatography. Results indicate that an ethanol intake of 11 g/kg b.wt. per day produce a significant reduction of the liver mitochondrial respiration tested with all the substrates used, including acetaldehyde. In contrast, the activity of AlDH in disrupted mitochondria remained unchanged. These results are in accord with the idea that a progressive deterioration of liv
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceAlcohol
Keywordsdc.subjectAcetaldehyde oxidation
Keywordsdc.subjectEthanol intake
Keywordsdc.subjectMitochondrial function
Títulodc.titleEthanol intake: Effect on liver and brain mitochondrial function and acetaldehyde oxidation
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile