Diethylpropion in magisterial formulations. Influence of cellulosis derivatives on in vitro stability and availability Dietilpropión en formulaciones magistrales. Influencia de derivados celulósicos en la estabilidad y disponibilidad in vitro.
Author
dc.contributor.author
Gómez Gómez, Fredy Arizmendy
Author
dc.contributor.author
Alvarez Alvarez, Miguel Adrián
Author
dc.contributor.author
Cid,
Admission date
dc.date.accessioned
2019-01-29T14:53:01Z
Available date
dc.date.available
2019-01-29T14:53:01Z
Publication date
dc.date.issued
1993
Cita de ítem
dc.identifier.citation
Revista medica de Chile, Volumen 121, Issue 9, 2018, Pages 1013-1016
Identifier
dc.identifier.issn
00349887
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/161163
Abstract
dc.description.abstract
The aim of this work was to assess the degree of interaction between diethylpropion and some cellulosic derivatives widely used in anorexigenic prescriptions. Our in vitro results show that sodium carboxymethylcellulose and methylcellulose cause a significant degradation of diethylpropion, the first having a greater effect. Dissolution essays showed that the availability of the drug is vastly reduced by cellulosic derivatives. Provided the close relation between the dissolution and absorption characteristics of a drug, it is possible to predict that this association will result in a poor bioavailability.
Diethylpropion in magisterial formulations. Influence of cellulosis derivatives on in vitro stability and availability Dietilpropión en formulaciones magistrales. Influencia de derivados celulósicos en la estabilidad y disponibilidad in vitro.