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Authordc.contributor.authorVega Blanco, María Margarita 
Authordc.contributor.authorCastillo, Teresita 
Authordc.contributor.authorRetamales, Iván 
Authordc.contributor.authorLas Heras, Jorge 
Authordc.contributor.authorDevoto, Luigi 
Authordc.contributor.authorVidela Cabrera, Luis
Cita de ítemdc.identifier.citationFree Radical Biology and Medicine, Volumen 17, Issue 6, 2018, Pages 493-499
Abstractdc.description.abstractThe steroidogenic capacity and oxidative stress-related parameters of the human corpus luteum (CL) at different stages of the luteal phase were studied under basal and human chorionic gonadotropin (hCG)-stimulated conditions. Mid CL exhibited the maximal steroidogenic capacity, together with lower levels of glutathione and higher thiobarbituric acid reactants content, macrophage count, and superoxide dismutase (SOD) activity, compared to the late CL. Addition of hCG to luteal cell cultures led to a preferential increase in progesterone synthesis in the late CL compared to the mid CL, without changes in the oxidative stress-related parameters, except for the increased SOD activity found in the late CL. It is concluded that an oxidative stress condition is established in the mid CL, coinciding with the maximal steroidogenic capacity and macrophage infiltration of the organ, which be of relevance as one of the major mechanisms initiating CL involution in the human. © 1994.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceFree Radical Biology and Medicine
Keywordsdc.subjectFree radicals
Keywordsdc.subjectHuman luteal cell regression
Keywordsdc.subjectLipid peroxidation
Keywordsdc.subjectOxidative stress
Keywordsdc.subjectSuperoxide dismutase
Títulodc.titleSteroidogenic capacity and oxidative stress-related parameters in human luteal cell regression
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile