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Authordc.contributor.authorFernández, Virginia 
Authordc.contributor.authorVidela Cabrera, Luis 
Admission datedc.date.accessioned2019-01-29T14:55:19Z
Available datedc.date.available2019-01-29T14:55:19Z
Publication datedc.date.issued1995
Cita de ítemdc.identifier.citationFree Radical Biology and Medicine, Volumen 19, Issue 3, 2018, Pages 359-363
Identifierdc.identifier.issn08915849
Identifierdc.identifier.other10.1016/0891-5849(95)00016-Q
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/161335
Abstractdc.description.abstractAdministration of single doses of 0.1 mg L-triiodothyronine (T3)/kg for 3 consecutive days to fed rats produced a drastic increase in the respiratory burst activity of isolated polymorphonuclear leukocytes (PMN), stimulated with serum-opsonized zymosan. This effect was evidenced by the 3.8-fold increment in the integrated chemiluminescence, and seems to be primarily related to the enhanced activity of NADPH oxidase elicited by T3 treatment, with the observed higher myeloperoxidase activity playing a contributory role. In these conditions, hyperthyroidism determines a net enhancement in the oxidant capacity of PMN, as the increased rate of O2 - generation found occurs in the absence of changes in the activity of superoxide dismutase. © 1995.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceFree Radical Biology and Medicine
Keywordsdc.subjectChemiluminescence
Keywordsdc.subjectFree radicals
Keywordsdc.subjectHyperthyroidism
Keywordsdc.subjectMyeloperoxidase
Keywordsdc.subjectNADPH oxidase
Keywordsdc.subjectPolymorphonuclear leukocytes
Keywordsdc.subjectRespiratory burst activity
Keywordsdc.subjectSuperoxide dismutase
Keywordsdc.subjectSuperoxide radical production
Títulodc.titleOn the mechanism of thyroid hormone-induced respiratory burst activity in rat polymorphonuclear leukocytes
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile