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Author | dc.contributor.author | Labarca, Rodrigo | |
Author | dc.contributor.author | Gajardo, Maria Ines | |
Author | dc.contributor.author | Seguel, Mario | |
Author | dc.contributor.author | Silva, Hernan | |
Author | dc.contributor.author | Jerez, Sonia | |
Author | dc.contributor.author | Ruiz, Aida | |
Author | dc.contributor.author | Bustos, Gonzalo | |
Admission date | dc.date.accessioned | 2019-01-29T14:55:26Z | |
Available date | dc.date.available | 2019-01-29T14:55:26Z | |
Publication date | dc.date.issued | 1995 | |
Cita de ítem | dc.identifier.citation | Progress in Neuropsychopharmacology and Biological Psychiatry, Volumen 19, Issue 3, 2018, Pages 467-473 | |
Identifier | dc.identifier.issn | 02785846 | |
Identifier | dc.identifier.other | 10.1016/0278-5846(94)00027-F | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/161367 | |
Abstract | dc.description.abstract | 1. 1. The effects of acute D-amphetamine administration to rats on the release of endogenous excitatory amino acids from nucleus accumbens slices were studied. 2. 2. D-amphetamine (5 mg/kg and 10 mg/kg; i.p.) significantly increased the spontaneous release of aspartate and glutamate from nucleus accumbens slices. 3. 3. In contrast, D-amphetamine either produced no change or rather decreased K+ (40 mM)-evoked and N-methyl-D-aspartate (100 μM)-evoked release of aspartate and glutamate from the slices, respectively. 4. 4. When D-amphetamine treated rats were pretreated with haloperidol, the effects of D-amphetamine on the spontaneous release of excitatory amino acids were not produced, whereas its effects on N-methyl-D-aspartate-evoked release remained unchanged. 5. 5. These data suggest that amphetamine produces changes in excitatory amino acid-mediated transmission in the nucleus accumbens, that may play a role in amphetamine-induced behavioral or psychotomimetic effects. © 1995. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Progress in Neuropsychopharmacology and Biological Psychiatry | |
Keywords | dc.subject | aspartate | |
Keywords | dc.subject | D-amphetamine | |
Keywords | dc.subject | excitatory amino acids | |
Keywords | dc.subject | glutamate | |
Keywords | dc.subject | haloperidol | |
Keywords | dc.subject | nucleus accumbens | |
Título | dc.title | Effects of d-amphetamine administration on the release of endogenous excitatory amino acids in the rat nucleus accumbens | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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