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Authordc.contributor.authorCassorla Goluboff, Fernando 
Authordc.contributor.authorMericq, Verónica 
Authordc.contributor.authorEggers, Martha 
Authordc.contributor.authorAvila, Alejandra 
Authordc.contributor.authorGarcía, Cristian 
Authordc.contributor.authorFuentes, Ariel 
Authordc.contributor.authorRose, Susan R. 
Authordc.contributor.authorCutler, Gordon B. 
Cita de ítemdc.identifier.citationJournal of Clinical Endocrinology and Metabolism, Volumen 82, Issue 12, 2018, Pages 3989-3992
Abstractdc.description.abstractTo study the effect of delaying epiphyseal fusion on the growth of GH- deficient children, we studied 14 pubertal, treatment naive. GH-deficient patients (6 girls and 8 boys) in a prospective, randomized, placebo- controlled trial. Chronological age was 14.5 ± 0.5 yr, and bone age was 11.6 ± 0.3 yr (mean ± SEM) at the beginning of the study. Patients were assigned randomly to receive GH and LH-releasing hormone (LHRH) analog (n = 8) or GH and placebo (n = 6) during 3 yr, with planned continuation of GH treatment until epiphyseal fusion. Patients were measured with a stadiometer and had serum LHRH tests, serum testosterone (boys), serum estradiol (girls), and bone age performed every 6 months. Patients treated with GH and LHRH analog showed a clear suppression of their pituitary-gonadal axis and a marked delay in bone age progression. We observed a greater gain in height prediction in these patients than in the patients treated with GH and placebo after 3 yr of treatment (mean ± SEM, 14
Publisherdc.publisherEndocrine Society
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceJournal of Clinical Endocrinology and Metabolism
Keywordsdc.subjectEndocrinology, Diabetes and Metabolism
Keywordsdc.subjectClinical Biochemistry
Keywordsdc.subjectBiochemistry (medical)
Títulodc.titleEffects of luteinizing hormone-releasing hormone analog-induced pubertal delay in growth hormone (GH)-deficient children treated with GH: Preliminary results
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile